Cayman AIMP1 (human, recombinant)

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1), also known as p43, is a component of the multi-aminoacyl-tRNA synthetase complex and also functions as a cytokine. Intracellular AIMP1 interacts with and stabilizes arginyl-tRNA synthetase, as well as negatively regulates TGF-β signaling by binding to and stabilizing Smurf2. AIMP1 can also be secreted from cells in response to stimuli including hypoxia, heat shock, and TNF-α, and secreted AIMP1 has a variety of roles in the regulation of angiogenesis, fibroblast proliferation, and glucose homeostasis.^,, It also has pro-inflammatory activity and activates monocytes/macrophages, leading to the secretion of TNF-α, IL-8, and chemokine (C-C motif) ligand 2 (CCL2). Peripheral blood and synovial fluid levels of AIMP1 are elevated in patients with rheumatoid arthritis compared with peripheral blood isolated from healthy patients, and administration of the chimeric AIMP1 neutralizing antibody atliximab attenuates disease severity in a mouse model of collagen-induced arthritis. Intravenous administration of recombinant AIMP1 reduces tumor growth in an MKN45 stomach cancer mouse xenograft model. Cayman’s AIMP1 (human, recombinant) protein consists of 318 amino acids and has a calculated molecular weight of 35 kDa.

WARNING This product is not for human or veterinary use.