Cayman Tnfsf4 Extracellular Domain (Human, Recombinant), 100 G

TNF ligand superfamily member 4 (TNFSF4), also known as OX40L, is a type II transmembrane protein and the cognate ligand of the T cell co-stimulatory TNF receptor TNFRSF4, also known as OX40.^, TNFSF4 assembles into trimers, with each monomer possessing an approximately 132-amino acid extracellular domain comprised of a TNF homology domain followed by a C-terminal extension. It is upregulated in antigen-presenting cells, including B cells, macrophages, and dendritic cells, in response to antigen presentation, and is also expressed in mast cells, activated T cells, and certain endothelial cells. Binding of a TNFSF4 trimer to three TNFRSF4 monomers promotes T cell survival and memory, as well as an effector T cell phenotype, enhances cell mobility, and increases the production of effector cytokines. Polymorphisms in TNFSF4 are associated with susceptibility to systemic lupus erythematosus (SLE) and systemic sclerosis.^, Cayman’s TNFSF4 Extracellular Domain (human, recombinant) protein can be used for ELISA. This protein is a disulfide-lined homodimer. The reduced monomer, comprised of TNFSF4 (amino acids 51-183) fused to mouse IgG1 Fc at its N-terminus, consists of 369 amino acids and has a calculated molecular weight of 42.1 kDa. As a result of glycosylation, the monomer migrates at approximately 50 kDa by SDS-PAGE under reducing conditions.

WARNING This product is not for human or veterinary use.