Cayman Somatotropin Long Isoform (human, recombinant)

Somatotropin is a circulating peptide hormone encoded by GH1 in humans that has roles in growth, cellular proliferation and differentiation, muscle and bone anabolism, and lipolysis. Alternative splicing of the GH1 pre-mRNA produces one full-length 22 kDa isoform and a short-length 20 kDa isoform, which has reduced affinity for the somatotropin receptor. Somatotropin contains a central hydrophobic core and a bundle of four α-helices that forms two somatotropin receptor binding sites. It is synthesized and stored by somatotrophs in the anterior pituitary gland and is secreted episodically as a monomer or dimer in a circadian rhythm that peaks during night sleep.^, Somatotropin production is induced by stimulation with growth hormone-releasing hormone, ghrelin, or sex steroids and inhibited by somatostatin, IGF-1, or glucocorticoid stimulation. Binding of somatotropin to the somatotropin receptor, which is ubiquitously expressed, activates a variety of intracellular signal transduction pathways, including JAK-STAT, that lead to IGF-1, MAPK, PPARγ (Item No. ), or SIRPα signaling.^,, Decreased serum levels of somatotropin have been found in patients with dwarfism. Increased somatotropin serum levels have been found in patients with acromegaly, a condition characterized by abnormal bone growth, and are positively correlated with early mortality.^, Caymans Somatotropin Long Isoform (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 212 amino acids and has a calculated molecular weight of 24.7 kDa.

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