Cayman Histone H3K4Me2 Monoclonal Antibody (RM135)

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.^, Dimethylation of histone H3 at lysine 4 (H3K4Me2) is found at active and primed, but inactive, loci.^, It is enriched in gene promoter regions and overlaps with transcription factor binding sites. Low tumor levels of H3K4Me2 positively correlate with decreased overall and disease-free survival in pancreatic cancer patients. Caymans Histone H3K4Me2 Monoclonal Antibody (RM135) can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.