Cayman 25-hydroxy Vitamin D3 Rabbit Monoclonal Antibody (Clone RM3)

25-hydroxy Vitamin D₃ is an intermediate in the biosynthesis of 1α,25-dihydroxy vitamin D₃ (calcitriol; Item No. ), a vitamin D receptor (VDR) agonist that has multiple functions, including stimulation of calcium absorption, insulin secretion, and cell proliferation and differentiation.^,, It is produced from vitamin D₃ (Item No. ) by 25-hydroxylase/CYP2R1 and bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream where it is the major circulating form of vitamin D. 25-hydroxy Vitamin D₃ is transported to the kidney where it is hydroxylated by 1α-hydroxylase/CYP27B1 or 24-hydroxylase/CYP24A1 to produce 1α,25-dihydroxy vitamin D₃ or 24,25-dihydroxy vitamin D₃, respectively. Conversion of 25-hydroxy vitamin D₃ to 1α,25-dihydroxy vitamin D₃ is stimulated by parathyroid hormone (PTH) and inhibited by calcium, phosphorus, or FGF23. Serum 25-hydroxy vitamin D₃ levels have been widely used as a marker of vitamin D status. Increased serum 25-hydroxy vitamin D₃ levels are associated with increased bone density in patients with osteoarthritis, as well as reduced risk of colorectal, breast, and prostate cancer, whereas decreased serum 25-hydroxy vitamin D₃ levels have been found in children with nutritional rickets, a condition caused by vitamin D deficiency and characterized by reduced bone density.^,, Caymans 25-hydroxy Vitamin D₃ Rabbit Monoclonal Antibody (Clone RM3) can be used for ELISA.

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