Cayman Akt1E17K/Akt2E17K Rabbit Monoclonal Antibody (Clone RM336)

Akt1 and Akt2, also known as protein kinase Bα (PKBα) and PKBβ, respectively, are serine/threonine kinase belonging to the AGC kinase family and two of three Akt isoforms in mammals.^, Akt kinases function downstream of activated tyrosine kinases and PI3K to regulate a variety of cellular processes, including cell size, growth, proliferation, and survival, as well as genome stability, glucose metabolism, and neovascularization. They are comprised of an N-terminal pleckstrin homology (pH) domain, which binds to phosphatidylinositol-(3,4,5)-triphosphate (PIP₃) and phosphatidylinositol-(3,4)-diphosphate (PIP₂), a kinase domain, and a C-terminal regulatory hydrophobic motif. Akt1 and Akt2 are ubiquitously expressed and are the primary isoforms in endothelial cells and insulin-responsive tissues, respectively. Akt1^E17K is an activating mutation that has been found in tumor tissue isolated from patients with breast, colorectal, or ovarian cancer. Akt2^E17K mutations have been found in patients with hypoglycemia. Caymans Akt1^E17K/Akt2^E17K Rabbit Monoclonal Antibody (Clone RM336) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.

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