Cayman Acetyl-CoA Carboxylase 1 Rabbit Monoclonal Antibody (Clone RM232)

Acetyl-CoA carboxylase 1 (ACC1) is a biotin-dependent enzyme that catalyzes the conversion of acetyl-CoA (Item No. ) to malonyl-CoA (Item No. ), a building block in the biosynthesis of long-chain fatty acids.^,, It is found at high levels in the liver and adipose tissue and is localized to the cytosol. Expression of ACC1 is increased by sterol regulatory element binding protein-1a (SREBP-1a) and SREBP-1c, which are induced by insulin, as well as the lipid precursors inositol and choline (Item No. ). ACC1 activity is increased by citrate and inhibited by binding to long-chain acyl-CoAs or by phosphorylation by a number of kinases, including AMPK and TAK1.^,, ACC1 has critical roles in fatty acid synthesis and regulation of insulin levels. It is involved in numerous pathological conditions, including metabolic diseases such as diabetes and non-alcoholic fatty liver disease (NAFLD), as well as cancer and bacterial infections. Caymans Acetyl-CoA Carboxylase 1 Rabbit Monoclonal Antibody (Clone RM232) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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