Cayman Cytokeratin 8 (C-Term) Rabbit Monoclonal Antibody (Clone RM266)

Cytokeratin 8 is a type II epithelial intermediate filament protein. It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 8 is expressed in single-layered epithelial cells and epithelial-derived tumor cells. It dimerizes with the type I epithelial intermediate filament protein cytokeratin 18 to form a network of filament bundles throughout the cytoplasm. The tail of cytokeratin 8 binds to plasminogen and mediates invasiveness of cancer cells in vitro. A null mutation in KRT8, the gene encoding cytokeratin 8, is embryonic lethal in C57BL/6 x 129Sv, but not FVB/N, mice, which develop colorectal hyperplasia. Substitution mutations in KRT8, corresponding to residues in the head domain of the protein, disrupt filament reorganization following oxidative and non-oxidative stress in vitro and are associated with cryptogenic liver disease. Intratumoral levels of cytokeratin 8 and -18 are correlated with poor prognosis in patients with squamous cell carcinomas of the oral cavity. Cayman’s Cytokeratin 8 (C-Term) Rabbit Monoclonal Antibody (Clone RM266) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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