Cayman EGFR (Phospho-Tyr1173) Rabbit Monoclonal Antibody (Clone RM269)

Epidermal growth factor receptor (EGFR), also known as HER1 and ERBB1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival.^, It is a transmembrane receptor composed of an intracellular tyrosine kinase domain, a transmembrane lipophilic segment, and an extracellular domain that is expressed in epithelial, mesenchymal, and neuronal tissues.^,, Under unstimulated conditions, EGFR is an auto-inhibited monomer in the plasma membrane. Upon canonical ligand binding, EGFR undergoes homodimerization or heterodimerization with HER2, HER3, or HER4, which induces a conformational change in the cytoplasmic domain that facilitates autophosphorylation and intracellular signaling. EGFR contains five C-terminal autophosphorylation sites, tyrosine 1068 (Tyr¹⁰⁶⁸), Tyr¹¹⁴⁸, Tyr¹¹⁷³, Tyr¹⁰⁸⁶, and Tyr⁹⁹². EGFR autophosphorylation at Tyr¹¹⁷³ (phospho-Tyr¹¹⁷³) leads to interaction with phospholipase Cγ (PLCγ) and Shc, which have roles in activating the MAPK signaling pathway. Increased levels of EGFR (phospho-Tyr¹¹⁷³) are associated with poor progression-free survival in patients with non-small cell lung cancer (NSCLC). Levels of EGFR (phospho-Tyr¹¹⁷³) are increased in, and positively correlate with activation of MAPK signaling and cytokine production in, bronchial epithelial biopsies from healthy individuals exposed to diesel exhaust. Cayman’s EGFR (Phospho-Tyr¹¹⁷³) Rabbit Monoclonal Antibody (Clone RM269) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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