Cayman Integrin β1/CD29 Rabbit Monoclonal Antibody (Clone RM285)

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions. The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin β1, also known as CD29, is an integrin subunit that heterodimerizes with α integrin subunits, forming 12 different α-β integrin heterodimers that function as receptors for a variety of ECM proteins, including collagens, fibronectins, and laminins, and mediate outside-in and inside-out signaling cascades that regulate numerous cellular processes, including proliferation, adhesion, survival, migration, and organogenesis. Integrin β1 is expressed in most tissues, with high levels found in epidermal stem cells.^, Increased tumor levels of integrin β1 have been found in patients with lung or breast cancer and are associated with decreased overall survival. Caymans Integrin β1/CD29 Rabbit Monoclonal Antibody (Clone RM285) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.