Cayman PDGFRβ/CD140b (C-Term) Rabbit Monoclonal Antibody (Clone RM303)

PDGFRβ, also known as CD140b, is a type I transmembrane glycoprotein and receptor tyrosine kinase encoded by PDGFRB in humans. It is composed of five extracellular immunoglobulin-like (Ig-like) domains, a transmembrane domain, and an intracellular kinase domain. PDGFRβ is ubiquitously expressed and functions as a homodimer or a heterodimer with PDGFRα. Binding of the growth factor PDGF-BB or PDGF-DD to PDGFRβ promotes homodimerization, induces receptor autophosphorylation and a conformational change that facilitates access to the intracellular kinase domain, and intracellular signaling through multiple pathways, including ERK/MAPK, PI3K/AKT/mTOR, PLC/PKC, and JAK/STAT.^,, Knockdown of Pdgfrb decreases the number of vascular smooth muscle cells, induces CNS-specific reduction in pericytes, and is postnatally lethal in mice. De novo mutations in PDGFRB have been found in patients with novel overgrowth syndrome. Cayman’s PDGFRβ/CD140b (C-Term) Rabbit Monoclonal Antibody (Clone RM303) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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