Cayman PLAP (N-Term) Rabbit Monoclonal Antibody (Clone RM317)

Placental alkaline phosphatase (PLAP) is the placenta-specific isoenzyme of AP encoded by the ALPP gene in humans.^, It exists as a homodimer where each monomer is composed of an N-terminal α-helix and a crown domain that stabilize PLAP homodimers, a Zn²⁺- and mg²⁺-containing active site with a catalytic serine residue, and a non-catalytic metal-binding site occupied by Ca²⁺.^, PLAP is predominately expressed by syncytiotrophoblasts in the placenta and is tethered to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor.^, It is also present at low levels in the cervix, ovaries, and type I pneumocytes, as well as in the serum.^, Increased PLAP activity has been found in tumor tissue and cerebrospinal fluid (CSF) isolated from patients with intracranial germ cell tumors. Caymans PLAP (N-Term) Rabbit Monoclonal Antibody (Clone RM317) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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