Cayman hCG Rabbit Monoclonal Antibody (Clone RM330)

Human chorionic gonadotropin (hCG) is glycoprotein hormone secreted during pregnancy that has important roles in the maintenance of pregnancy.^, It exists as a heterodimer that is composed of two subunits, hCGα and hCGβ, that are subject to glycosylation, generating a variety of glycosylated hCG variants that have distinct biological functions.^, The expression of genes encoding hCGα and hCGβ are regulated by a variety of hormones, growth factors, and cytokines. It is secreted by placental trophoblasts during early pregnancy and serum hCG levels peak from gestational weeks 7 to 10. hCG has numerous roles in pregnancy, including stimulating production of progesterone from the corpus luteum and promoting angiogenesis of uterine vasculature and the growth of fetal organs. Urinary hCG levels have been commonly used in the determination of pregnancy. Increased serum, urinary, or tumor levels of hCGβ have been found in patients with a variety of cancers, including bladder, lung, cervical, or ovarian cancer, and are associated with poor prognosis. Caymans hCG Rabbit Monoclonal Antibody (Clone RM330) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. This antibody recognizes the hCGβ subunit in both the monomeric and hCGαβ heterodimeric forms.

WARNING This product is not for human or veterinary use.