Cayman Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody (Clone RM334)

Surfactant protein A (SP-A) is a hydrophilic surfactant protein and member of the collectin family with roles in microbial and apoptotic cell phagocytosis, as well as the regulation of cytokine expression.^,,, It is composed of an N-terminal cysteine-rich domain that facilitates crosslinking of SP-A monomers, a collagen-like domain that induces multimerization, and a C-terminal carbohydrate recognition domain (CRD) for pathogen recognition. SP-A is expressed primarily in pulmonary surfactant but is also expressed in the brain, kidney, and female reproductive tract. It functions as an octadecamer that binds bacterial, fungal, and viral pathogens to enhance opsonized phagocytosis. SP-A interacts with toll-like receptors to modulate the production of various cytokines and inflammatory mediators in response to infection.^,,, Serum levels of SP-A are associated with early relapse or exacerbation in patients with chronic obstructive pulmonary disease (COPD). Cayman’s Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody (Clone RM334) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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