Cayman AMACR (N-Term) Rabbit Monoclonal Antibody (Clone RM349)

α-methylacyl-Coenzyme A (α-methylacyl-CoA) racemase (AMACR) is an enzyme involved in the metabolism of branched chain fatty acids and 2-arylpropanoic acids (2-APAs), such as ibuprofen (Item No. ). It is expressed in most human tissues and is localized to peroxisomes and mitochondria.^, AMACR converts R-2-methyl fatty acids to S-2-methylacyl-CoA esters via an epimerization reaction prior to their degradation by β-oxidation. AMACR is overexpressed in localized and metastatic prostate cancer, as well as in a variety of other cancers. AMACR has been found selectively in patient-derived prostate cancer tumor tissue compared to non-cancer prostate tissue, and has been used as a biomarker of the disease. Mutations in AMACR resulting in reduced enzyme activity lead to the accumulation of R-2-methyl fatty acids and are associated with neurological and peroxisomal disorders. Cayman’s AMACR (N-Term) Rabbit Monoclonal Antibody (Clone RM349) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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