Cayman CD163 (N-Term) Rabbit Monoclonal Antibody (Clone RM371)

CD163 is a member of the scavenger receptor family that has a role in inflammation.^, It is composed of an N-terminal ectodomain, which contains nine scavenger receptor cysteine-rich (SRCR) class B domains that mediate protein-protein interactions, a transmembrane segment, and a short cytoplasmic tail.^, Alternative splicing of the CD163 pre-mRNA produces several isoforms, including three variants that differ in length of the cytoplasmic tail. CD163 is expressed on the surface of monocytes and macrophages and used as a marker of M2 alternatively activated macrophages. CD163 protein levels are increased by hemoglobin, IL-6, IL-10, or glucocorticoids and decreased by LPS, IL-4, TNF-α, or IFN-γ.^, It binds to and internalizes haptoglobin-hemoglobin (Hp-Hb) complexes, leading to degradation of the Hp-Hb complex and production of anti-inflammatory heme metabolites. A soluble form of CD163 (sCD163), resulting from proteolytic cleavage of membrane-bound CD163, has been found in plasma and other tissue fluids. CD163⁺ macrophages in inflamed tissues or plasma sCD163 levels are increased in numerous acute or chronic inflammatory diseases, including sepsis, atherosclerosis, rheumatoid arthritis, and multiple sclerosis.^, Caymans CD163 (N-Term) Rabbit Monoclonal Antibody (Clone RM371) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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