Cayman BOB-1/OBF-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM378)

B cell Oct Binding Factor 1 (BOB-1) is a transcription factor that has a role in B cell development and function. It contains a polypeptide region, a two-turn α-helix, and a disordered region. It is primarily expressed on B cells, with the highest expression in germinal center B cells, and transiently expressed on activated T cells. Its expression is induced by downstream signaling of B cell receptors, as well as IL-4, CD40 ligand (CD40L), and LPS. BOB-1 is a coactivator that is recruited to the POU domain of the transcription factors Oct-1 and Oct-2 and enhances their transactivation. Mice deficient in POU2AF1, the gene encoding BOB-1, have reduced numbers of transitional and mature B cells and lack a marginal zone B cell compartment and germinal center in the bone marrow, leading to deficits in secondary immunoglobulin isotype production.^, POU2AF1 is downregulated in classical, but not lymphocyte-predominant, Hodgkin lymphoma. Cayman’s BOB-1/OBF-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM378) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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