Cayman Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody (Clone RM386)

Cytokeratin 10 (CK-10) is a type I acidic epithelial intermediate filament protein. It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. CK-10 expression is induced upon keratinocyte differentiation, increasing during keratinocyte migration from the basal layer to the suprabasal layer of the epidermis. It dimerizes with the type II epithelial intermediate filament protein CK-1 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm. Increased tumor CK10 expression has been found in patients with hepatocellular carcinoma (HCC) and is associated with poor prognosis. CK10 mutations have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering. Caymans Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody (Clone RM386) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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