Cayman EGFRL858R Rabbit Monoclonal Antibody (RM380)

Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival.^, It is a 170 kDa transmembrane receptor composed of an intracellular tyrosine kinase domain, a transmembrane lipophilic segment, and an extracellular domain that is expressed in epithelial, mesenchymal, and neuronal tissues.^,, Under unstimulated conditions, EGFR is an auto-inhibited monomer in the plasma membrane. Upon canonical ligand binding, EGFR undergoes homodimerization or heterodimerization with HER2, HER3, or HER4, which induces a conformational change in the cytoplasmic domain that facilitates autophosphorylation and intracellular signaling. The exon 19 in-frame deletion mutant EGFR^L858R is found, often in conjunction with additional EGFR mutations, in non-small cell lung cancers (NSCLC) and is associated with increased susceptibility to tyrosine kinase inhibition and cell death.^, Cayman’s EGFR^L858R Rabbit Monoclonal Antibody (RM380) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.