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Cayman Despropionyl Para-Chlorofentanyl (Hydrochloride), N-(4-Chl
List Price
$356.00
Your Price
$356.00
Cayman Despropionyl Para-Chlorofentanyl (Hydrochloride), N-(4-Chlorophenyl)-1-Phenethylpiperidin-4-Amine, Monohydrochloride, 5 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-32514-5
MFG.PART:
32514-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM., It demonstrates weaker inhibition for DDR2 (IC50 = 413 nM) and has a good selectivity profile against a panel of 451 kinases. DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458 (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzamide, hydrate
Synonyms
- Discoidin Domain Receptor 1-IN-1
Molecular Formula
C30H31F3N4O3 • XH2O
Formula Weight
552.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMF:PBS(pH7.2) (1:2): 0.3 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 0.1 mg/ml
SMILES
O=C(NC1=CC=C(C)C(OC2=CC3=C(NC(C3)=O)C=C2)=C1)C4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4.O
InChi Code
InChI=1S/C30H31F3N4O3.H2O/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26;/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38);1H2
InChi Key
QSSRNPHRICJNHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32514-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 32514-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |