Cayman SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (recombinant; aa 21-243, 319-541) (His-tagged)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.^,,,, The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion. It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.^, The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.^,, In this way, ACE2 acts as the functional receptor for SARS-CoV-2. Caymans SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (recombinant; aa 21-243, 319-541) (His-tagged) protein can be used for ELISA, surface plasmon resonance (SPR), and Western blot (WB) applications.

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