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Cayman AAA
List Price
$253.00
Your Price
$253.00
Cayman AAA - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-32733-1
MFG.PART:
32733-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AAA is an antagonist of g protein-coupled receptor 75 (GPR75). It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 µM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells. In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension when administered prior to induction or after establishment of hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(20-hydroxy
Molecular Formula
C24H39NO6 • 2Na
Formula Weight
483.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: slightly soluble
- PBS (pH 7.2): 1 mg/mL
SMILES
OCCCC/C=C\CCCCCCC/C=C\CCCCC(NC(C([O-])=O)CC([O-])=O)=O.[Na+].[Na+]
InChi Code
InChI=1S/C24H41NO6.2Na/c26-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-22(27)25-21(24(30)31)20-23(28)29;;/h8-11,21,26H,1-7,12-20H2,(H,25,27)(H,28,29)(H,30,31);;/q;2*+1/p-2/b10-8-,11-9-;;
InChi Key
JGVHCBALWPPEGB-UJJOPKMPSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-32733-1 |
|---|---|
| Supplier Part Number | 32733-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 3055022-23-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |