We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman MLN120B
List Price $498.00 Your Price $498.00
Cayman MLN120B - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-32819-25
MFG.PART: 32819-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MLN120B is an inhibitor of IκB kinase β (IKKβ; IC50 = 45 nM).1 It is selective for IKKβ over a panel of 30 tyrosine and serine/threonine kinases (IC50s = >50 µM for all). MLN120B inhibits NF-κB activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an IC50 value of 2.8 µM in a reporter assay. It inhibits proliferation in a panel of six multiple myeloma cancer cell lines, including cell lines resistant to dexamethasone (Item No. 11015), melphalan (Item No. 16665), or doxorubicin (Item No. 15007), in a concentration-dependent manner.2 MLN120B (50 mg/kg) reduces serum levels of soluble human IL-6 receptor, a marker of INA-6 cell growth, in a SCID-hu mouse model of bone marrow-engrafted INA-6 multiple myeloma. It reduces paw swelling, as well as cartilage destruction and bone erosion in the inflamed joints, in a rat model of rheumatoid arthritis induced by complete Freunds adjuvant (CFA) with a median effective dose (MED) of 12 mg/kg.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(9CI, ACI)-N-
CAS Number
783348-36-7
Molecular Formula
C19H15ClN4O2
Formula Weight
366.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.50 mg/mL
SMILES
O=C(C1=CC=CN=C1C)NC2=C(C(Cl)=CC3=C2NC4=C3C=CN=C4)OC
InChi Code
InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25)
InChi Key
ZNOLRTPMNMPLHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32819-25 |
|---|---|
| Supplier Part Number | 32819-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 783348-36-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |