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Cayman HTI 286
List Price
$63.00
Your Price
$63.00
Cayman HTI 286 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-32852-1
MFG.PART:
32852-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
HTI 286 is an inhibitor of microtubule polymerization., It binds to (Kd = 260 nM) and inhibits the polymerization of tubulin in a cell-free assay when used at concentrations of 0.1 and 1 µM. HTI 286 (30 nM) induces cell cycle arrest at the g2/M phase and apoptosis in KB-3-1 epidermoid carcinoma cells. It inhibits cell growth in a panel of 18 tumor cell lines, including HCT-15 and DLD-1 colon cancer cells, which overexpress P-glycoprotein (mean IC50 = 2.5 nM). HTI 286 (1.6 mg/kg) reduces tumor volume in LOX, KB-3-1, KB-8-5, MX-1, DLD-1, and HCT-15 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N,β,β-tri
CAS Number
228266-40-8
Synonyms
- Taltobulin
- SPA 110
Molecular Formula
C27H43N3O4
Formula Weight
473.7
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 40 mg/mL
SMILES
CC(C)(C1=CC=CC=C1)[C@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O
InChi Code
InChI=1S/C27H43N3O4/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34)/b18-16+/t20-,21-,22-/m1/s1
InChi Key
CNTMOLDWXSVYKD-PSRNMDMQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32852-1 |
|---|---|
| Supplier Part Number | 32852-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 228266-40-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |