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Cayman SB-332235
List Price $283.00 Your Price $283.00
Cayman SB-332235 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-32869-10
MFG.PART: 32869-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SB-332235 is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2; IC50 = 9.3 nM in CHO cell membranes expressing the recombinant human receptor).1 It is selective for CXCR2 over CXCR1 (IC50 = 9,633 nM). SB-332235 (10 ng/mL) inhibits migration of isolated human peripheral blood monocytes induced by chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL5, or CXCL8 by 92, 73, and 50%, respectively.2 It decreases cigarette smoke-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration when administered at a dose of 1 mg/kg.3 SB-332235 (1 mg/kg) reduces increases in neuronal levels of 4-hydroxy nonenal (4-HNE; Item No. 32100) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in a rat model of Alzheimers disease.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-chloro-3-
CAS Number
276702-15-9
Molecular Formula
C13H10Cl3N3O4S
Formula Weight
410.7
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
SMILES
O=C(NC1=CC=C(C(S(N)(=O)=O)=C1O)Cl)NC2=C(Cl)C(Cl)=CC=C2
InChi Code
InChI=1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)
InChi Key
WTLRWOHEKQGKDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32869-10 |
|---|---|
| Supplier Part Number | 32869-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 276702-15-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |