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Cayman SB-204741
List Price
$85.00
Your Price
$85.00
Cayman SB-204741 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-32965-10
MFG.PART:
32965-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SB-204741 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B. It inhibits 5-HT-induced contraction of isolated rat stomach fundus, a tissue that endogenously expresses high levels of 5-HT2B receptors (PA2 = 7.95). SB-204741 is selective for 5-HT2B receptors over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, dopamine D1-3, histamine H1, α1- and α2-adrenergic, and GABAA receptors (Kis = 1-100 µM). In vivo, SB-204741 (1 mg/kg per day) prevents the development of pulmonary arterial hypertension (PAH) and reduces vascular stiffness in a Bmpr2 mutant mouse model of hereditary PAH. It also reduces blood pressure in DOCA-salt hypertensive rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(1-methyl-
CAS Number
152239-46-8
Molecular Formula
C14H14N4OS
Formula Weight
286.4
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMSO: 15 mg/mL
λmax
231, 270 nm
SMILES
O=C(NC1=CC(C=CN2C)=C2C=C1)NC3=CC(C)=NS3
InChi Code
InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
InChi Key
USFUFHFQWXDVMH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-32965-10 |
|---|---|
| Supplier Part Number | 32965-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 152239-46-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |