Cayman Isoguvacine (hydrochloride)

Isoguvacine is a GABA_A receptor agonist.¹ It binds to rat synaptic cortical membranes (K_i = 55 nM) and activates α₁β₂γ_2S, α₂β₂γ_2S, α₃β₂γ_2S, α₅β₂γ_2S, and ρ₁ subunit-contanining GABA_A receptors in a FLIPR assay (EC₅₀s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively).¹ It inhibits CA1 population spikes in rat hippocampal slices (EC₅₀ = 13 µM) and high potassium/low magnesium-induced seizures in rat pups.^2,3 Chronic administration of isoguvacine (2 mg/kg) improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).⁴

WARNING This product is not for human or veterinary use.