Cayman BIBP3226

BIBP3226 is a nonpeptide antagonist of neuropeptide Y (NPY) receptor Y₁ (K_i = 1.1 nM). It is selective for Y₁ over Y₂, Y₄, and Y₅ receptors (K_is = >1,000 nM for all). It also binds to neuropeptide FF receptor 1 (NPFF1) and NPFF2 (K_is = 108 and 79 nM, respectively) and reverses NPFF-induced inhibition of forskolin-induced cAMP accumulation in CHO Cells expressing human NPFF2 in a concentration-dependent manner. BIBP3226 inhibits NPY-induced increases in perfusion pressure in isolated rat kidney but not the NPY-induced twitch response in isolated rat vas deferens (IC₅₀s = 26 and >10,000 nM, respectively). BIBP3226 inhibits NPY-induced increases in blood pressure in pithed rats (ED₅₀ = 0.11 mg/kg). It also inhibits NPFF-induced hypothermia in mice when administered intracerebroventricularly (i.c.v.) at a dose of 5 nmol.

WARNING This product is not for human or veterinary use.