Cayman ACU 4429 (hydrochloride)

ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC₅₀ = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Item No. ) in the visual cycle. It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED₅₀ = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED₅₀ = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4^-/- mouse model of Stargardt disease (ED₅₀ = 0.47 mg/kg).

WARNING This product is not for human or veterinary use.