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Cayman TAS 205
List Price
$95.00
Your Price
$95.00
Cayman TAS 205 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-33261-1
MFG.PART:
33261-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 55.8 nM). It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 µM, as well as over enzyme and receptor panels at 10 µM. TAS 205 inhibits production of prostaglandin D2 (PGD2; Item No. ) induced by A23187 (Item No. ) in KU812 human and RBL-2H3 rat basophils with IC50 values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(1-methyl-
CAS Number
1584160-52-0
Molecular Formula
C27H36N6O4 • H2O
Formula Weight
526.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/mL
λmax
266 nm
SMILES
O=C(N1CCN(CC1)C(C2=CC=CN2C)=O)NC3=CC=C(N4CCC(CC4)C(N5CCOCC5)=O)C=C3.O
InChi Code
InChI=1S/C27H36N6O4.H2O/c1-29-10-2-3-24(29)26(35)31-13-15-33(16-14-31)27(36)28-22-4-6-23(7-5-22)30-11-8-21(9-12-30)25(34)32-17-19-37-20-18-32;/h2-7,10,21H,8-9,11-20H2,1H3,(H,28,36);1H2
InChi Key
NFXCKTKGAJDCBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-33261-1 |
|---|---|
| Supplier Part Number | 33261-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1584160-52-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |