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Cayman MTP 131 (acetate)
List Price $41.00 Your Price $41.00
Cayman MTP 131 (acetate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33302-1
MFG.PART: 33302-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MTP 131 is a mitochondria-targeted peptide antioxidant., It localizes to the mitochondria and reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 nM. MTP 131 (2 mg/kg) reduces infarct volume, hemispheric swelling, and glutathione (GSH) depletion in a mouse model of acute cerebral ischemia induced by middle cerebral artery occlusion (MCAO). It increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 5 mg/kg. MTP 131 reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
D-arginyl-2,6-
CAS Number
1334953-95-5
Synonyms
- Elamipretide
- SS-31
Molecular Formula
C32H49N9O5 • XC2H4O2
Formula Weight
639.8
Purity
≥95%
Formulation
A crystalline solid
Solubility
- PBS (pH 7.2): 10 mg/mL
SMILES
CC(C=C(C=C1C)O)=C1C[C@H](NC([C@H](N)CCCNC(N)=N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O.CC(O)=O
InChi Code
InChI=1S/C32H49N9O5.C2H4O2/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21;1-2(3)4/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38);1H3,(H,3,4)/t24-,25+,26+,27+;/m1./s1
InChi Key
UEYRJRBULBAAEG-NFWUDPOKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33302-1 |
|---|---|
| Supplier Part Number | 33302-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1334953-95-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |