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Cayman Savolitinib
List Price $81.00 Your Price $81.00
Cayman Savolitinib - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33332-1
MFG.PART: 33332-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Savolitinib is an inhibitor of c-Met (IC50 = 5 nM). It is selective for c-Met over a panel of 274 other kinases at 1 µM. Savolitinib inhibits c-Met autophosphorylation in NCI H441 human non-small cell lung cancer (NSCLC) cells (IC50 = 3 nM). It also inhibits proliferation of NCI H441 cells induced by HGF (Item No. ; IC50 = 6 nM) and in a panel of gastric cancer cells with dysregulated c-Met (EC50s = 0.6-14.7 nM)., Savolitinib (3 mg/kg) inhibits intratumor c-Met autophosphorylation by 94% and reduces tumor growth in an Hs 746T human stomach cancer mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[(1S)-1-
CAS Number
1313725-88-0
Synonyms
- AZD6094
- HMPL-504
- Volitinib
Molecular Formula
C17H15N9
Formula Weight
345.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/mL
- DMSO: 1 mg/mL
- DMSO:PBS (pH 7.2) (1:20): 0.05 mg/mL
λmax
225, 348 nm
SMILES
C[C@@H](C1=CN2C(C=C1)=NC=C2)N3C4=NC(C5=CN(C)N=C5)=CN=C4N=N3
InChi Code
InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChi Key
XYDNMOZJKOGZLS-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33332-1 |
|---|---|
| Supplier Part Number | 33332-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1313725-88-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |