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Cayman CVT-6883
List Price $128.00 Your Price $128.00
Cayman CVT-6883 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33333-5
MFG.PART: 33333-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CVT-6883 is an adenosine A2B receptor antagonist (Ki = 22 nM).1 It is selective for adenosine A2B over adenosine A1, A2A, and A3 receptors (Kis = 1,940, 3,280, and 1,070 nM, respectively), as well as a panel of 84 receptors, ion channels, transporters, and enzymes at 10 µM. CVT-6883 (6 mg/kg) decreases allergen challenge-induced bronchoalveolar lavage fluid (BALF) eosinophil and lymphocyte infiltration and airway reactivity in a mouse model of allergic asthma.2 It also decreases fibrosis in the non-infarct zone, improves ejection fractions, and reduces ventricular tachycardia in a rat model of myocardial infarction.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-ethyl-3,9-
CAS Number
752222-83-6
Synonyms
- GS-6201
Molecular Formula
C21H21F3N6O2
Formula Weight
446.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
λmax
236, 304 nm
SMILES
O=C1C2=C(N(CC)C(N1CCC)=O)N=C(C3=CN(CC4=CC=CC(C(F)(F)F)=C4)N=C3)N2O=C1C2=C(N(CC)C(N1CCC)=O)N=C(C3=CN(CC4=CC=CC(C(F)(F)F)=C4)N=C3)N2
InChi Code
InChI=1S/C21H21F3N6O2/c1-3-8-30-19(31)16-18(29(4-2)20(30)32)27-17(26-16)14-10-25-28(12-14)11-13-6-5-7-15(9-13)21(22,23)24/h5-7,9-10,12H,3-4,8,11H2,1-2H3,(H,26,27)
InChi Key
KOYXXLLNCXWUNF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33333-5 |
|---|---|
| Supplier Part Number | 33333-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 752222-83-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |