Cayman Pam2CSK4 (trifluoroacetate salt)

Pam₂CSK₄ is a synthetic bacterial lipopeptide and an agonist of the toll-like receptor 2 (TLR2).¹ It is selective for the TLR2/TLR6 heterodimer over TLR2/TLR1 (EC₅₀s = 0.015 and 4.12 ng/mL, respectively, in reporter assays using human receptors). Pam₂CSK₄ increases the levels of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in RAW 264.7 macrophages when used at a concentration of 100 ng/mL.² It stimulates osteoclast formation, induces gingival inflammation, and decreases alveolar bone mass in a mouse model of periodontitis when administered at a dose of 5 µg/animal.³ Pam₂CSK₄ (10 µg/vaccine), when used as an adjuvant, reduces parasite burden and enhances the response to antigen, as measured by IgG levels, in a mouse model of lymphatic filariasis induced by B. malayi.⁴

WARNING This product is not for human or veterinary use.