Cayman MF438

MF438 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1; IC₅₀ = 2.3 nM for the rat enzyme), an enzyme that catalyzes the formation of a cis double bond at the ∆⁹ position of stearoyl-CoA to produce oleoyl-CoA.^1,2 It reduces spheroid formation in NCI H460 and patient-derived non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner, an effect that can be blocked by oleic acid (Item Nos. 90260 | 24659).³ MF438 (1 µM) decreases the activity of aldehyde dehydrogenase 1A1 (ALDH1A1), a marker of cancer stem cells (CSCs), in NCI H460-derived spheroids when used at a concentration of 1 µM. It acts synergistically with cisplatin (Item No. 13119) to induce apoptosis and autophagy in patient-derived NSCLC cells.⁴

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