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Cayman MI-463
List Price
$36.00
Your Price
$36.00
Cayman MI-463 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-33525-1
MFG.PART:
33525-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MI-463 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 15 nM). It inhibits growth of mouse bone marrow cells (BMCs) expressing the MLL fusion protein MLL-AF9 (GI50 = 0.23 µM), as well induces differentiation of MLL-AF9-transformed BMCs. MI-463 (0.75-6 µM) reduces colony formation by patient-derived acute myeloid leukemia (AML) cells. It reduces tumor growth in an MV4-11 mouse xenograft model when administered at a dose of 35 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-methyl-5-[[4-
CAS Number
1628317-18-9
Molecular Formula
C24H23F3N6S
Formula Weight
484.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: soluble
- Ethanol: soluble
λmax
226, 230, 279, 287 nm
SMILES
N#CC1=CC2=C(C)C(CN3CCC(CC3)NC4=C5C=C(CC(F)(F)F)SC5=NC=N4)=CC=C2N1
InChi Code
InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32)
InChi Key
DZACSLYTXLZAAF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33525-1 |
|---|---|
| Supplier Part Number | 33525-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1628317-18-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |