Cayman Podophyllotoxin-d6

Podophyllotoxin-d₆ is intended for use as an internal standard for the quantification of podophyllotoxin (Item No. ) and picropodophyllotoxin (Item No. ) by GC- or LC-MS. Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.^,,,, It inhibits polymerization of isolated chicken brain tubulin (IC₅₀ = 0.6 µM) and induces mitotic arrest at the g₂/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/mL.^, Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells. It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC₅₀s = 0.0098-0.017 µM). Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide (Item No. ) and teniposide (Item No. ). Formulations containing podophyllotoxin have been used in the treatment of external genital warts.

WARNING This product is not for human or veterinary use.