Cayman Sulfadiazine-d4

Sulfadiazine-d₄ is intended for use as an internal standard for the quantification of sulfadiazine (Item No. ) by GC- or LC-MS. Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.^,,, It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. ) to dihydropteroate, an intermediate in folate biosynthesis. Sulfadiazine inhibits recombinant P. carinii DHPS (IC₅₀ = 0.19 μM). It is active against clinical isolates of M. tuberculosis (MIC₉₀ = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L).^, Sulfadiazine is also active against A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s = <0.5 mg/mL for all) when used in combination with trimethoprim (Item No. ). In vivo, sulfadiazine (40 mg/kg per day) increases survival in a mouse model of lethal T. gondii infection when administered in combination with pyrimethamine (Item No. ). Formulations containing sulfadiazine have been used in the treatment of rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.

WARNING This product is not for human or veterinary use.