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Cayman Nicorandil-d4
List Price $69.00 Your Price $69.00
Cayman Nicorandil-d4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33608-1
MFG.PART: 33608-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil (Item No. ) by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel KIR6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor., It is selective for SUR2B/KIR6.2 over the SUR2A/KIR6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM). It decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs when administered intravenously at a dose of 1 mg/kg. Nicorandil increases survival and decreases infarct size in a rabbit model of myocardial ischemia-reperfusion injury induced by left coronary artery occlusion. Formulations containing nicorandil have been used in the treatment of angina pectoris.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-(nitro
CAS Number
1132681-23-2
Synonyms
- 2-Nicotinamidoethyl nitrate-d4
Molecular Formula
C8H5D4N3O4
Formula Weight
215.2
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility
- DMSO: soluble
SMILES
O=C(C1=C([2H])N=C([2H])C([2H])=C1[2H])NCCO[N+]([O-])=O
InChi Code
InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)/i1D,2D,3D,6D
InChi Key
LBHIOVVIQHSOQN-VTBMLFEUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33608-1 |
|---|---|
| Supplier Part Number | 33608-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1132681-23-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |