Cayman JAK2 (human, recombinant)

JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling.^, It is composed of N-terminal FERM and SH2 domains, a regulatory pseudokinase domain, and a C-terminal kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.^, Activation of these cytokine receptors activates JAK2 and induces its dimerization and kinase activity, leading to JAK2 phosphorylation of STAT transcription factors and transcription of immune-related target genes. JAK2 signaling is inhibited by the suppressor of cytokine signaling (SOCS) proteins SOCS-1 and SOCS-3.^, Gain-of-function mutations in JAK2 are associated with various blood disorders, including leukemias and myeloproliferative neoplasms. Cayman’s JAK2 (human, recombinant) protein can be used for enzyme activity assays.

WARNING This product is not for human or veterinary use.