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Cayman GNE-6640
List Price $530.00 Your Price $530.00
Cayman GNE-6640 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33751-50
MFG.PART: 33751-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GNE-6640 is an inhibitor of ubiquitin-specific protease 7 (USP7; IC50 = 0.75 µM).1 It is selective for USP7 over USP47 and USP5 (IC50s = 20.3 and >200 µM, respectively). GNE-6640 enhances ubiquitination of the USP7 substrate MDM2 in HCT116 colon cancer cells (IC50 = 0.23 µM) and reduces cell viability in a panel of 108 cell lines (IC50s = <10 µM for all). GNE-6640 (10-70 µM) enhances apoptosis induced by doxorubicin (Item No. 15007) or cisplatin (Item No. 13119) in MCF-7 and U2OS cancer cells, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[2-amino-4-
CAS Number
2009273-67-8
Molecular Formula
C20H18N4O
Formula Weight
330.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/mL
- DMSO: 1 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: slightly soluble
SMILES
OC1=CC=C(C2=C(N)N=CC(C3=CC=C4NN=CC4=C3)=C2CC)C=C1
InChi Code
InChI=1S/C20H18N4O/c1-2-16-17(13-5-8-18-14(9-13)10-23-24-18)11-22-20(21)19(16)12-3-6-15(25)7-4-12/h3-11,25H,2H2,1H3,(H2,21,22)(H,23,24)
InChi Key
ZHYXJQQBKROZDX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33751-50 |
|---|---|
| Supplier Part Number | 33751-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2009273-67-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |