Cayman 5,7-Dihydroxy-4-methylcoumarin

5,7-Dihydroxy-4-methylcoumarin is a synthetic coumarin with diverse biological activities.^,,,,,, It scavenges alkylperoxy radicals and hypochlorous acid (HOCl; IC₅₀ = 2.85 µM) in cell-free assays, as well as inhibits lipid peroxidation in rat liver microsomes, A23187-induced thromboxane B₂ (TXB₂; Item No. ) generation in isolated rat peritoneal leukocytes, and myeloperoxidase (MPO) activity in a cell-free assay (IC₅₀s = 12, 1, and 1.06 µM, respectively).^, 5,7-Dihydroxy-4-methylcoumarin also inhibits rat lens aldose reductase (IC₅₀ = 17 µM) and human carbonic anhydrase I (CAI), CAIX, and CAXII with K_i values of 8.4, 0.19, and 6.4 µM, respectively.^, It inhibits platelet aggregation induced by arachidonic acid (Item Nos. | | ) with an IC₅₀ value of 45 µM. 5,7-Dihydroxy-4-methylcoumarin inhibits hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase (IC₅₀ = 47.2 µM). It is active against H. pylori with an MIC value of 10 µg/mL.

WARNING This product is not for human or veterinary use.