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Cayman TP-0463518
List Price
$194.00
Your Price
$194.00
Cayman TP-0463518 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-33788-25
MFG.PART:
33788-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TP-0463518 is a pan hypoxia-inducible factor prolyl hydroxylase (HIF-pH) inhibitor.1 It inhibits human HIF-PH1 (Ki = 5.3 nM), as well as human HIF-PH2 and HIF-PH3 (IC50s = 18 and 63 nM, respectively). TP-0463518 (5 mg/kg) increases serum levels of erythropoietin (EPO) in mice. It also increases serum EPO levels in a 5/6 nephrectomy-induced rat model of chronic kidney disease when administered at a dose of 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[1-[[6-(4-
CAS Number
1558021-37-6
Molecular Formula
C20H18ClN3O6
Formula Weight
431.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.3 mg/mL
- DMSO: 25 mg/mL
λmax
231, 274 nm
SMILES
O=C(CNC(C1=C(O)CCN(CC2=CN=C(C=C2)OC3=CC=C(C=C3)Cl)C1=O)=O)O
InChi Code
InChI=1S/C20H18ClN3O6/c21-13-2-4-14(5-3-13)30-16-6-1-12(9-22-16)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
InChi Key
HMMHKGLPKAQOOH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33788-25 |
|---|---|
| Supplier Part Number | 33788-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1558021-37-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |