Cayman Penicillamine-d3

Penicillamine-d₃ is intended for use as an internal standard for the quantification of D-penicillamine (Item No. ) by GC- or LC-MS. Penicillamine is an orally bioavailable copper chelator and penicillin degradation product.^, It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels. Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene. Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Item No. ) and 7-nitroindazole (Item No. ). Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.

WARNING This product is not for human or veterinary use.