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Cayman Tuftsin (human) (trifluoroacetate salt)
List Price $69.00 Your Price $69.00
Cayman Tuftsin (human) (trifluoroacetate salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33804-10
MFG.PART: 33804-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tuftsin is an endogenous peptide generated by proteolysis of leukokinin that stimulates phagocytosis. It binds human polymorphonuclear leukocytes (PMN), human monocytes, and mouse macrophages with Kd values of 130, 125, and 53 nM, respectively. Tuftsin (200 nM) increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages. It increases phagocytosis of the bacteria S. aureus and L. monocytogenes, as well as the fungus S. oviformis, by isolated human, mouse, rabbit, dog, or guinea pig phagocytes when used at concentrations ranging from 0.01 to 0.15 µg/mL. Tuftsin (0.1, 0.5, and 25 mg/kg) increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
L-threonyl-L-
Synonyms
- Thr-Lys-Pro-Arg
Molecular Formula
C21H40N8O6 • XCF3COOH
Formula Weight
500.6
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 25 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 30 mg/mL
- PBS (pH 7.2): 10 mg/mL
SMILES
C[C@@H](O)[C@H](N)C(N[C@@H](CCCCN)C(N1[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C21H40N8O6.C2HF3O2/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;3-2(4,5)1(6)7/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);(H,6,7)/t12-,13+,14+,15+,16+;/m1./s1
InChi Key
FMTUDMCZOOBIBT-GYFKHDNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33804-10 |
|---|---|
| Supplier Part Number | 33804-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |