Cayman Naringenin Chalcone

Naringenin chalcone is a flavonoid that has been found in the skin of red tomatoes and has diverse biological activities.^,, It inhibits the proliferation of SENCAR mouse skin transformed (SST) cells and SENCAR mouse skin transformed tumor (SST-T) cells (IC₅₀s = 92 and 184 µg/mL). Naringenin chalcone (50 µg/animal) reduces the number of papillomas in a mouse model of skin carcinogenesis induced by phorbol 12-myristate 13-acetate (TPA; Item No. ). Topical administration of naringenin chalcone reduces ear edema in a mouse model of TPA-induced inflammation. Naringenin chalcone (0.8 mg/kg) reduces airway hyperresponsiveness, bronchoalveolar lavage fluid (BALF) eosinophil infiltration, and lung mucus production in a mouse model of ovalbumin-induced allergic asthma.

WARNING This product is not for human or veterinary use.