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Cayman Isoalantolactone
List Price $77.00 Your Price $77.00
Cayman Isoalantolactone - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33838-50
MFG.PART: 33838-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Isoalantolactone is a sesquiterpene lactone that has been found in Inula and has diverse biological activities.1,2,3,4 It inhibits the proliferation of PANC-1, BxPC-3, and HPAC pancreatic cancer cells (IC50s = 40, 43, and 48 µM, respectively), as well as induces apoptosis, cell cycle arrest at the S phase, and the production of reactive oxygen species (ROS) in PANC-1 cells.2 Isoalantolactone (4 and 8 µM) decreases LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), IL-6, and TNF-α in RAW 264.7 macrophages.4 It reduces the production of S. aureus α-toxin in a concentration-dependent manner and increases survival in a mouse model of S. aureus-induced pneumonia when administered at a dose of 50 mg/kg.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3aR,4aS,8aR,
CAS Number
470-17-7
Synonyms
- (+)-Isoalantolactone
- NSC 241036
Molecular Formula
C15H20O2
Formula Weight
232.3
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 1 mg/mL
SMILES
C[C@]12[C@@](C(CCC2)=C)([H])C[C@@]3([H])[C@@](OC(C3=C)=O)([H])C1
InChi Code
InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h11-13H,1-2,4-8H2,3H3/t11-,12+,13-,15-/m1/s1
InChi Key
CVUANYCQTOGILD-QVHKTLOISA-N
Origin
Plant/Aucklandia lappa Decne
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33838-50 |
|---|---|
| Supplier Part Number | 33838-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 470-17-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |