Cayman HT-2157

HT-2157 is an antagonist of the galanin-3 receptor (GAL₃; K_i = 17 nM).¹ It is selective for GAL₃ over GAL₁ and GAL₂ (K_is = >10 µM for both). HT-2157 (10 µM) induces apoptosis in various cell types, including HL-60 leukemia and BV-2 murine microglial cells, as well as isolated human peripheral blood mononuclear cells (PBMCs).² It decreases operant alcohol, sucrose, and saccharin self-administration in rats when administered at a dose of 30 mg/kg.³ HT-2157 (3 and 10 mg/kg) increases drinking in the Vogel punished drinking task and reduces immobility time in the forced swim test in rats, indicating anxiolytic- and antidepressant-like activities, respectively.⁴

WARNING This product is not for human or veterinary use.