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Cayman BCI-121
List Price $528.00 Your Price $528.00
Cayman BCI-121 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-33854-50
MFG.PART: 33854-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BCI-121 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3).1 It inhibits histone H3 lysine 4 (H3K4) di- and trimethylation in HT-29 cell lysates when used at a concentration of 100 µM. BCI-121 (100 µM) inhibits proliferation in a panel of colorectal, lung, pancreatic, prostate, and ovarian cancer cell lines in an SMYD3 expression-dependent manner. It induces cell cycle arrest at the S phase and decreases global H5K4 methylation and H3K4 dimethylation in HT-29 cells in a concentration-dependent manner. Intratumoral injection of BCI-121 (20 µM) reduces tumor volume in an MHCC97H hepatocellular carcinoma (HCC) mouse xenograft model.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(amino
CAS Number
432529-82-3
Molecular Formula
C14H18BrN3O2
Formula Weight
340.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 10 mg/mL
λmax
253 nm
SMILES
O=C(C1CCN(CC1)CC(NC2=CC=C(C=C2)Br)=O)N
InChi Code
InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4,10H,5-9H2,(H2,16,20)(H,17,19)
InChi Key
KSUYPIXCRPCPGF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33854-50 |
|---|---|
| Supplier Part Number | 33854-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 432529-82-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |