Cayman Pyridoxamine (hydrochloride)

Pyridoxamine is a 4-methylamine form of vitamin B₆ that is converted to pyridoxal 5-phosphate (Item No. 20352), the active form of vitamin B₆, and an important cofactor for metabolism.¹ It scavenges isoketals in cell-free assays and inhibits the formation of lysyl-levuglandin-lactam adducts in dazoxiben-stimulated isolated human platelets when used at concentrations of 0.1 and 1 mm.² Pyridoxamine (1 g/L in the drinking water) inhibits the development of acellular capillaries and accumulation of N^ε-(1-carboxymethyl)-L-lysine (CML; Item No. 16483) in the retina in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).³ It reverses STZ-induced deficits in the novel object recognition task in a rat model of diabetes when administered in the drinking water at concentrations of 0.4 and 1 g/L.⁴

WARNING This product is not for human or veterinary use.